About Luigi Franciosi
Over 20 Years of Experience
Luigi Franciosi is an established consultant with over twenty years or experience. He finished his Masters and his Doctorate at the University of British Columbia in Vancouver where he is currently an adjunct professor in pharmacology. Franciosi continued his studies in business at the University of Warwick in the UK. He then went on to be a Chief Operating Officer at Verona Pharma for seven years. Presently, Franciosi is a pharmaceutical industry consultant of his own business.
References
Verona Pharma
London, UK
Chief Operating Officer
Universiteit Leiden
Leiden, The Netherlands
Gorlaeus Laboratories; Leiden/Amsterdam Center for Drug Research
The University of British Columbia
Vancouver, Canada
Department of Anesthesiology, Pharmacology, and Therapeutics
Refereed Publications
View Luigi Franciosi’s Research Portal
1. Lavorini F, Spina D, Walker MJ, Franciosi L, Page CP, Fontana GA. Antitussive effect of carcainium chloride in patients with chronic cough and idiopathic interstitial pneumonias: A pilot study. Pulmonary Pharmacology & Therapeutics. Oct; 40: 91-94, 2016.
2. Franciosi LG, Diamant Z, Banner K, Zuiker R, Morelli N, Kamerling I, De Kam M, Burggraaf J, Cohen AF, Cazzola M, Calzetta L, Singh D, Spina D, Walker M, Page CP. Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials. The Lancet (Respiratory Medicine) 1 (9): 714-727, 2013.
3. Cazzola M, MacNee W, Martinez FJ, Rabe KF, Franciosi LG, Barnes PJ, Brusasco V, Burge PS, Calverley PM, Celli BR, Jones PW, Mahler DA, Make B, Miravitlles M, Page CP, Palange P, Parr D, Pistolesi M, Rennard SI, Rutten-van Mölken MP, Stockley R, Sullivan SD, Wedzicha JA, Wouters EF; American Thoracic Society; European Respiratory Society Task Force on outcomes of COPD. European Respiratory Journal 31 (2):416-69, 2008.
4. Franciosi LG, Page CP, Celli B, Cazzola, M, Walker MJA, Danhof M, Rabe KF, Della Pasqua OE. Markers of Exacerbation Severity in Chronic Obstructive Pulmonary Disease. Respiratory Research 10; 7:74, 2006.
5. Franciosi LG, Page CP, Celli B, Cazzola, M, Walker MJA, Danhof M, Rabe KF, Della Pasqua OE. Markers of Disease Severity in Chronic Obstructive Pulmonary Disease. Pulmonary Pharmacology & Therapeutics 19 (3):189-99, 2006.
6. Nguan C, Franciosi LG, Butterfield NN, MacLeod BA, Jens M, Fenster HN. A Prospective, Double-blind, Randomised Cross-over Study Evaluating Changes in Urinary pH for Relieving the Symptoms of Interstitial Cystitis. British Journal of Urology International 95 (1): 91-94, 2005.
7. Schwarz SKW, Butterfield NN, MacLeod BA, Kim EY, Franciosi LG, Ries CR. Under “Real World” Conditions, Desflurane Increases Drug Cost Without Speeding Discharge After Short Ambulatory Anesthesia Compared to Isoflurane. Canadian Journal of Anesthesia 51 (9): 892-898, 2004.
8. Butterfield NN, Ries CR, Schwarz SKW, Franciosi LG, MacLeod BA, Day B. Combined pre- and postsurgical bupivacaine wound infiltrations decrease postoperative opioid requirements after knee ligament reconstruction. Canadian Journal of Anesthesia 48 (3): 245-250, 2001.
- Ries CR, Azmudéh A, Franciosi LG, Schwarz SKW, MacLeod BA. Cost comparison of sevoflurane with isoflurane anesthesia in arthroscopic menisectomy surgery. Canadian Journal of Anesthesia 46 (11): 1008-1013, 1999.
- Schwarz SKW, Franciosi LG, Ries CR, Regan WD, Davidson RG, Nevin K, Escobedo S, MacLeod BA. Addition of femoral 3-in-1 blockade to intra-articular ropivacaine 0.2% does not reduce analgesic requirements following arthroscopic knee surgery. Canadian Journal of Anesthesia 46 (8): 741-747, 1999.
1. Franciosi LG, Zuiker R, Kamerling IMC, Burgraaf J, Cohen AF, Walker M & Page CP. RPL554, a dual PDE3/4 inhibitor, is well tolerated and maintains bronchodilator activity when administered by inhalation to mild-to-moderate allergic asthmatics on 6 consecutive days. (Accepted Abstract – Poster). American Thoracic Society Annual Meeting, 17-22 May 2013, Philadelphia, PA, USA.
2. Franciosi LG, Diamant Z, Morelli N, Kam M, Cohen A, Walker M, & Page CP. A Combined Phase I/IIa Study of the Safety, Bronchodilator and Bronchoprotective Effects of Nebulized RPL554, a dual PDE3/4-inhibitor, in Healthy Subjects and Asthmatics. (Abstract – Oral). ISAF-International Severe Asthma Forum, 11-13 Oct. 2012, Gothenburg, Sweden.
3. Franciosi LG, Della Pasqua OE. Markers of Disease Severity in COPD Patients with Exacerbations (Abstract – Poster or Oral). American Thoracic Society Annual Meeting, 19-24 May 2006, San Diego, California, USA.
4. Franciosi LG, Yang SY, Della Pasqua OE. Assessment of the Probability of COPD Exacerbations Using Poisson Regression Models (Abstract Poster & Oral). British Pharmacology Society Winter Meeting, 20-22 December 2005, London, United Kingdom.
5. Franciosi LG, Page CP, Celli B, Cazzola, M, Walker MJA, Danhof M, Rabe KF, Della Pasqua OE: Markers of Exacerbation Severity in Chronic Obstructive Pulmonary Disease (Abstract – Poster). European Respiratory Society Congress Annual Congress, 17-21 September 2005, Copenhagen, Denmark.
6. Franciosi LG, Della Pasqua OE. Clinical Study Measures Not Sensitive to the Severity of Chronic Obstructive Pulmonary Disease (Abstract – Poster). American Thoracic Society Annual Meeting, 20-25 May 2005, San Diego, California, USA.
7. Franciosi LG, Page CP, Celli B, Cazzola, M, Walker MJA, Danhof M, Rabe KF, Della Pasqua OE. Which Markers other than FEV1 Reflect Disease Progression in Chronic Obstructive Pulmonary Disease (Abstract – Poster & Oral). European Respiratory Society Annual Congress, 4-8 September 2004, Glasgow, Scotland.
8. Franciosi LG, Butterfield NN, MacLeod BA. Randomized Controlled Trial of a Clinical Trial Protocol Generating Module (Abstract – Poster). MEDINFO2004 (Hosted by the International & American Medical Informatics Associations), 7-11 September 2004, San Francisco, California, USA.
9. Franciosi LG, Della Pasqua OE: Lack of Correlation Between Clinical Endpoints and COPD Disease Progression (Abstract – Poster). World Congress of Clinical Pharmacology (Hosted by the American/ Society for Clinical Pharmacology and Therapeutics), 1-6 August 2004, Brisbane, Australia.
10. Nguan C, Franciosi LG, Butterfield NN, MacLeod BA, Jens M, Fenster HN. A Prospective, Double-blind, Randomised Cross-over Study Evaluating Changes in Urinary pH for Relieving the Symptoms of Interstitial Cystitis (Abstract – Poster & Oral). American Urological Association Annual Meeting, 8-13 May 2004, San Francisco, California, USA.
11. Butterfield NN, Kim EY, Schwarz SKW, Ries CR, Franciosi LG, MacLeod BA. Comparison of isoflurane and desflurane for short ambulatory anesthesia: Drug cost and recovery profiles. Anesthesia & Analgesia. 94(2S): S118, 2002.
12. Franciosi LG, Butterfield NN, MacLeod BA, Walker MJW, Sutter MC. Development and Evaluation of a Quality Assessment Instrument for Clinical Trial Protocols (Abstract – Poster). XIVth World Congress of Pharmacology, 7-12 July 2002, San Francisco, California, USA.
13. Butterfield B.B., MacLeod BA, Graf P., Zis AP, Eyre J, Nafde N, Franciosi LG, Walker MJA. Cognitive Recovery Following ECT: A Comparison Between Thiopentone and Propofol Anesthesia (Abstract – Poster). XIVth World Congress of Pharmacology, 7-12 July 2002, San Francisco, California, USA.
14. Gilhuly T, MacLeod BA, Franciosi LG, Butterfield BB, Chan S, Tabrizchi R. Evaluation of the Dose Response and Pharmacokinetics of Conopeptide G1 in the Rabbit Model (Abstract – Poster). XIVth World Congress of Pharmacology, 7-12 July 2002, San Francisco, California, USA.
15. Franciosi LG, Butterfield NN, MacLeod BA. Evaluating the Process of Generating a Clinical Trial Protocol. Proceedings of the American Medical Informatics Association Annual Symposium, p.1021, 2002.
16. Franciosi LG, MacLeod BA, Huzmezan MH, Ticea C, Cosma A. A Web-Based Clinical Trial Expert System; Human Information and Education Systems. Proceedings of Systemics, Cybernetics and Informatics Society 8: 242-247, 2001
17. Franciosi LG, MacLeod BA, Huzmezan MI, Ticea C, Cosma A, Rubenson K. Preliminary Evaluation of A Protocol Generating System. Proceedings of the Western Pharmacology Society 44: 212, 2001.
18. Ries CR, Butterfield NN, MacLeod BA, Franciosi LG. Breast Block for Breast Surgery (Abstract – Poster). 12th World Congress of Anaesthesiologists, 4th June 2000, Montreal, QB, Canada.
19. Lang CC, Murugasu J, Lee TC, Franciosi LG, Doci A, Ali AB: Clinical evaluation of RSD921 as a local anaesthetic in patients undergoing venous cannulation for elective treatment. Clinical Pharmacology & Therapeutics 67 (2): PIII-1, 142, Feb. 2000.
20. Franciosi LG, Murugasu J, Ali SB, Doci A, Lee, TC, and Lang CC. Phase II Clinical Trial of RSD921 as a Local Anaesthetic in Patients Undergoing Venous Cannulation for Elective Treatment. Journal of Clinical Pharmacology 39 (9): A32, 977, Sept. 1999.
21. Doci A, Murugasu J, Ali SB, Franciosi LG, Lee TC, Lang CC: Local anesthetic effects of intradermal RSD921 in healthy subjects. Clinical Pharmacology & Therapeutics 65 (2): PIII-2, 177, Feb. 1999
22. Schwarz SKW, MacLeod BA, Ries CR, Franciosi LG, Regan WD, Davidson RG, Nevin K, Escobedo S: Femoral 3-in-1 block for post-operative pain control in arthroscopic cruciate ligament repair. Canadian Journal of Anesthesia 45 PII: A37, 1998.
23. MacLeod BA, Azmudéh A, Franciosi LG, Ries CR, Schwarz SKW: Evaluation of the cost of sevoflurane compared to isoflurane anesthesia. Canadian Journal of Anesthesia 45 PII: A26, 1998.
24. Polyakov GM, Boyle JC, Olssen P, Salvian AJ, Franciosi LG, Bain AI (Abstract). Efficacy of Aero-Therapeutic Wound Management (ATM): A Preliminary Study of ATM with Burns – Phase I. (Abstract – Poster) Second Asian-Pacific Burns Conference, 8–11 February 1996, Hong Kong, China.
25. Polyakov GM, Boyle JC, Olssen P, Salvian AJ, Franciosi LG, Bain AI. Efficacy of Aero-Therapeutic Wound Management (ATM): A Preliminary Study of ATM with Peripheral Vascular Disease – Phase I. (Abstract – Poster) ‘Frontiers in Surgery’. The Seventh Wilson TS Wang International Surgical Symposium, 1–3 December 1995, Hong Kong, China.
1. Franciosi LG, MacLeod BA. Clinical Trial Expert Systems (Abstract – Oral). Automation and Robotics: The Key For Computer Integrated Health Care Delivery. Workshop Program by The Peter Wall Institute for Advanced Studies at UBC, 10-12 April 2002, Vancouver, Canada.
2. Franciosi LG, Butterfield NN, MacLeod BA. Expert Systems: Certifying Tools for New Therapies (Abstract – Oral). Symposium on Computer Controlled Drug Therapy, 13-14 July 2001, Vancouver, Canada.
3. Franciosi LG, Butterfield NN, MacLeod BA. Development of a Web-Based Clinical Trial Expert System at UBC (Abstract – Oral). UBC Faculty of Medicine Golden Jubilee, 1st November 2000, Vancouver, Canada.
4. Franciosi LG. Intraspinal NMDA Antagonists (Dextromethorphan) in Mice (Abstract – Oral). UBC Health Sciences Student Research Forum, 12th October 1993, Vancouver, Canada.
5. Franciosi LG, Clinical Evaluation of Intradermal RSD2000 as Peripheral Analgesic in Subjects with Capsaicin-Induced Pain (Abstract – Oral). UBC Health Sciences Student Research Forum, 16th October 1996, Vancouver, Canada.
1. Markers of Disease & Exacerbation Severity in Chronic Obstructive Pulmonary Disease. British Pharmacological Society Winter Meeting – Institute of Education Respiratory SIG Symposium Entitled, “Current and Future Treatment Strategies for Chronic Obstructive Pulmonary Disease”: Hosts. Dr. Domenico Spina, King’s College London & Dr. Alexandre Trifilileff, Novartis (Symposium Organisers), 21st December 2005, London, United Kingdom.
2. Markers & Modelling of Disease Progression. Research Seminars at the Pharmaceutical Science Research Division, King’s College London, United Kingdom. Host: Dr. Domenico Spina (Reader in Pharmacology), 12th January 2005, London, United Kingdom.
3. Exacerbations of COPD. Research Seminar Series at the Leiden/Amsterdam Center for Drug Research (LACDR), Leiden University. Host: Professor Dr. Meindert Danhof (LACDR Director & Head of Division of Pharmacology), 9th November 2004, Leiden, The Netherlands.
4. Markers of Disease Progression in Stable Chronic Obstructive Pulmonary Disease. Grand Rounds, Department of Pulmonology, Leiden University Medical Center (LUMC). Hosts: Professors. Drs. Klaus Rabe & Peter Sterk (Pulmonogists), 20th March 2004, Leiden, The Netherlands.
5. Review of the Medical Literature for Possible Disease Markers in Stable COPD. Research Seminar Series at the Leiden/Amsterdam Center for Drug Research (LACDR), Leiden University. Host: Professor Dr. Meindert Danhof (Head of the Division of Pharmacology), 9th December 2003, Leiden, The Netherlands.
6. Disease Progression and Therapeutic Response in Chronic Obstructive Pulmonary Disease (COPD). Grand Rounds, Department of Pulmonary, Critical Care & Sleep Medicine, St. Elizabeth’s Medical Center, Tufts University. Host: Professor Bartolome Celli (Pulmonary Specialist), 23rd September 2003, Boston, MA, USA.
7. Good Clinical Practices. Work in Progress (WiP) Rounds at the Canadian HIV Trials Network & BC Centre for Excellence, St. Paul’s Hospital, Vancouver, BC. Host: Dr. D. Zarowny (Senior Scientific Officer). 20th April 1995, Vancouver, BC, Canada.
8. Aero-Therapeutic Wound Management in Burns and Peripheral Vascular Disease. Grand Rounds, Department of Vascular and General Surgery, St. Paul’s Hospital, Vancouver, BC. Hosts: Dr. W. Cole (Surgeon-in-Chief), Dr. J. Reid (Vascular Surgeon), and Dr. T. Maxwell (Vascular Surgeon). 23rd March 1995, Vancouver, BC, Canada.
9. Clinical Pharmacology Research Organization (CPRO): Support for Clinical Research. Grand Rounds: Department of Anesthesia, Vancouver General Hospital – UBC Site. Host: Drs. David Bevan (Head) and B. MacLeod (Practicing Anaesthetist). 21st March 1995, Vancouver, Canada.
10. Aero-Therapeutic Wound Management in Burns and Peripheral Vascular Disease. Grand Rounds, Department of Plastic Surgery, Vancouver Hospital and Health Sciences Centre, Vancouver, BC; Hosts: Dr. J. Boyle (Director of the Burn Unit & Plastic Surgeon) and Dr. C. Snelling (Head of Research Services & Plastic Surgeon). 8th March 1995, Vancouver, Canada.
11. Aero-Therapeutic Wound Management in Burns and Peripheral Vascular Disease. Registered Nurses’ Association of BC & BC Children’s Hospital, Vancouver, BC. Host: Ms. Elaine Baxter (RN & Association President). 17th October 1995, Vancouver, Canada.
12. Aero-Therapeutic Wound Management in Burns and Peripheral Vascular Disease. Canadian Department of National Defense, Ottawa, Ontario; Vancouver Representative & Host: Dr. DRG Brown (Lieutenant-Commander and General Surgeon). 6th February 1995, Vancouver, Canada.